Study Finds Menopause Symptoms Can Be PredictedThe number of eggs left in a woman's ovaries are like the grains of sand in an hourglass, ticking away the hours on her biological clock.Researchers now say they may be able to predict when that clock will wind down. And while doctors can't actually count the number of eggs in an ovary, they can measure ovarian volume. British researchers say there's a direct correlation between the two, and by measuring ovarian volume with transvaginal ultrasound, doctors should be able to predict when menopause will set in and how many fertile years a woman has left. According to the study authors, this information will revolutionize the care of women looking for assisted reproductive technologies, including those who were treated for childhood cancers as well as women who want to put off starting a family for whatever reason. Although information still needs to be validated in clinical studies, its benefit is most likely to start with women who are being treated for cancer and women attending fertility clinics, said Tom Kelsey, co-author of the study appearing June 17 in the journal Human Reproduction. "If women looking for some sort of assisted conception and their physicians know that they've got a long time till menopause, then you could plan for a range of treatments," said Kelsey, who is a senior research fellow at the University of St. Andrews in Scotland. "If you knew menopause was likely in four to five years, you'd plan a different set of IVF [in vitro fertilization] treatments." Others reiterate, however, that the findings should be treated with caution. "Should a young woman who is 30 years old go for a test to figure out whether she's got three, five or 10 years left on her fertility? Should she make career decisions and life decisions? Are these data good enough to make those determinations?" asked Dr. Alan Copperman, director of reproductive medicine at Mount Sinai Medical Center in New York City. "The answer is obviously no to all of those questions. The predictive value of this test is not good enough to go and tell someone to change their life." According to the article, eggs form in a female's ovary while she is still in the womb, peaking at several million about halfway through gestation and then starting a continuous decline. At birth, there are several hundred thousand and, when menstruation begins, about 300,000. At about age 37, a woman has about 25,000 eggs left, and at menopause only about 1,000. The time at which menopause sets in is widely believed to be based on the number of eggs reaching a critically low threshold. The authors of this study measured ovarian volume with transvaginal ultrasound, then looked at the relationship between ovarian volume -- ovaries shrink as a woman ages -- and number of eggs. They then applied mathematical and computer models to predict menopause. The study authors are negotiating with a medical school to set up clinical trials. The idea would be to follow women to see if their predictions were indeed correct. While these authors have come up with a tool to potentially help women plan their lives, a second study in the same issue of Human Reproduction warned that women might not want to leave it too late. Assisted reproductive technology (ART) could not be relied upon to fully compensate for lack of natural fertility after the age of 35, the article stated. The authors used a computer simulation model to determine that the overall success rate of assisted reproductive technology would be 30 percent for those attempting to get pregnant from age 30, 24 percent for those trying from age 35, and 17 percent from age 40. SOURCES: Tom Kelsey, Ph.D., senior research fellow, University of St. Andrews, St. Andrews, Scotland; Alan Copperman, M.D., director, reproductive medicine, Mount Sinai Medical Center, New York; June 17, 2004, Human Reproduction |
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ScienceDirect - Fertility and Sterility : Reproductive Urinary Reproductive Urinary Metabolites during the Perimenopause may explain the subfertility seen in the perimenopause, via decreased implantation rates. Birth control during perimenopause - Yahoo! Health Women typically ovulate irregularly during perimenopause. Was this article helpful? Tell us what you think. Be the first to rate! Sign in to rate! Birth control pills and perimenopause from Women to Women Explains birth control pills in perimenopause including information about Birth control pills also offer some positives, like lower rates of endometrial Understanding Menopause Fertility rates begin dropping steeply between ages 35 and 38 and fall to less Itâ™s one reason some women use oral contraceptives during perimenopause. Contraception in the perimenopause Diaphragms have a relatively high failure rate, but they are more commonly used by older women with a lower rate of natural fertility 56. Perimenopause: The Complex Endocrinology of the Menopausal The physiology of the perimenopausal increased rate of spinal bone loss (as . Thus the perimenopause and its resulting loss of fertility and social Amazon.com: Perimenopause--Preparing for the Change, Revised 2nd Rate this item to improve your recommendations Fertility and Infertility is discussed at length as is sexuality and Menopause. Managaing Fertility in Perimenopause Years Fertility control in the perimenopausal period takes careful consideration. Although pregnancy rates are lower, the health risks of unexpected pregnancy can Contraception Online Slides - perimenopause, contraception During perimenopause, normal ovulation transitions to anovulation, which is followed by a permanent loss of ovarian function. Although fertility rates Contraception Online: Contraception and Reproductive Health Info Average failure rates with copper IUDs and the levonorgestrel-releasing For more information about birth control options in the perimenopause, Ask The Doctor: Birth Control and Perimenopause Perimenopause is a transition time during which the production of Fertility rates decrease with increasing age, and by the late 40s are quite low. Female Infertility: Perimenopause and Fertility Treatments This article explains the effects that perimenopause has on fertility Success rates for IVF treatments are as high as 25% in women under the age of 40. Developmental Disabilities Health Alliance - Perimenopause and Despite declining fertility during perimenopause, women in their forties can Complications are rare, and failure rates range about 1% to 3% over ten BioMed Central | Full text | Perimenopausal contraception in Similarly, the rate of condom usage among perimenopausal women in the study was of all medical methods for fertility regulation during fertile years. Femalepatient.com However, the rate of atresia varies from woman to woman. Despite the decline in fertility during perimenopause, women should be aware that pregnancy is Contraceptive Options for Perimenopausal Women The decreased fertility rate among perimenopausal women allows some latitude when contraceptive methods with suboptimal efficacies are selected; however, Perimenopausal Conception -- TARLATZIS and ZEPIRIDIS 997 (1): 93 Key Words: perimenopausal conception ⢠reproduction ⢠fertility potenial ⢠ovary .. Cumulative conception and live birth rates after oocyte donation: |
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