Study Finds Menopause Symptoms Can Be Predicted

The number of eggs left in a woman's ovaries are like the grains of sand in an hourglass, ticking away the hours on her biological clock.

Researchers now say they may be able to predict when that clock will wind down.

And while doctors can't actually count the number of eggs in an ovary, they can measure ovarian volume. British researchers say there's a direct correlation between the two, and by measuring ovarian volume with transvaginal ultrasound, doctors should be able to predict when menopause will set in and how many fertile years a woman has left.

According to the study authors, this information will revolutionize the care of women looking for assisted reproductive technologies, including those who were treated for childhood cancers as well as women who want to put off starting a family for whatever reason.

Although information still needs to be validated in clinical studies, its benefit is most likely to start with women who are being treated for cancer and women attending fertility clinics, said Tom Kelsey, co-author of the study appearing June 17 in the journal Human Reproduction.

"If women looking for some sort of assisted conception and their physicians know that they've got a long time till menopause, then you could plan for a range of treatments," said Kelsey, who is a senior research fellow at the University of St. Andrews in Scotland. "If you knew menopause was likely in four to five years, you'd plan a different set of IVF [in vitro fertilization] treatments."

Others reiterate, however, that the findings should be treated with caution.

"Should a young woman who is 30 years old go for a test to figure out whether she's got three, five or 10 years left on her fertility? Should she make career decisions and life decisions? Are these data good enough to make those determinations?" asked Dr. Alan Copperman, director of reproductive medicine at Mount Sinai Medical Center in New York City. "The answer is obviously no to all of those questions. The predictive value of this test is not good enough to go and tell someone to change their life."

According to the article, eggs form in a female's ovary while she is still in the womb, peaking at several million about halfway through gestation and then starting a continuous decline. At birth, there are several hundred thousand and, when menstruation begins, about 300,000. At about age 37, a woman has about 25,000 eggs left, and at menopause only about 1,000.

The time at which menopause sets in is widely believed to be based on the number of eggs reaching a critically low threshold.

The authors of this study measured ovarian volume with transvaginal ultrasound, then looked at the relationship between ovarian volume -- ovaries shrink as a woman ages -- and number of eggs. They then applied mathematical and computer models to predict menopause.

The study authors are negotiating with a medical school to set up clinical trials. The idea would be to follow women to see if their predictions were indeed correct.

While these authors have come up with a tool to potentially help women plan their lives, a second study in the same issue of Human Reproduction warned that women might not want to leave it too late. Assisted reproductive technology (ART) could not be relied upon to fully compensate for lack of natural fertility after the age of 35, the article stated.

The authors used a computer simulation model to determine that the overall success rate of assisted reproductive technology would be 30 percent for those attempting to get pregnant from age 30, 24 percent for those trying from age 35, and 17 percent from age 40.

SOURCES: Tom Kelsey, Ph.D., senior research fellow, University of St. Andrews, St. Andrews, Scotland; Alan Copperman, M.D., director, reproductive medicine, Mount Sinai Medical Center, New York; June 17, 2004, Human Reproduction

perimenopause and soy
Soy phytoestrogens for perimenopausal symptoms - Yahoo! Health
Isoflavones are a type of phytoestrogen. Compared with the American diet, traditional Asian diets include large amounts of soy, which is high in isoflavones

IngentaConnect Soy for the treatment of perimenopausal symptoms-a
The aim of this study was to evaluate the benefit of soy preparations for the treatment of perimenopausal symptoms by performing a systematic review of

Maturitas : Soy for the treatment of perimenopausal symptomsâ”a
RCTs of soy for perimenopausal symptoms were considered if they scored three or above on the Jadad scale 17. This scale measures the likelihood of bias

Discovery Health :: Solutions for Seven Symptoms of Perimenopause
2 percent natural progesterone skin cream helps 85 percent of perimenopausal women; apply ÂĽ tsp. daily to skin. Soy foods like soy milk and tofu (aim for

Menopause Perimenopause Mature Sexuality Aging HRT Womens Health
Soy, for example, contains plant estrogens. Eating soy foods or taking soy supplements may be helpful for hot flashes and other perimenopausal symptoms,

Before the Change: Taking Charge of Your Perimenopause with The
The soy isoflavones are known to specifically help relieve perimenopausal symptoms such as hot flashes, mood swings, anxiety, and flushing, block estrogen's

Bellevue Pharmacy | Soy May Support A Healthier Perimenopause
(1-10) Soy consumption has been shown to significantly improve a woman's comfort and health during perimenopause, menopause and postmenopause.

Alternative Therapies - HRT, Perimenopause and Menopause
Soy products may also provide some relief. But before you start stocking up on Perimenopause is the period before menopause, which occurs approximately

Perimenopause naturally: an integrative medicine approach
On average, the onset of perimenopause occurs around age 47, . Several studies have now been done on the effect of soy isoflavones on vasomotor symptoms,

Hotflash! - FAQ - The Joy of Soy
Dr. Love discusses, the proper role of HRT for perimenopause and menopause, the risk of estrogen in breast cancer survivors, the use of soy in

Women's Herbal Wisdom | Transformations and alterations mark a
Studies on soyâ™s effectiveness during perimenopause have been Lee believes the emphasis should shift from popping soy during perimenopause to regularly

Hotflash! - Bender4 - Soy & Perimenopause
Soy & Perimenopause Interview from the "Power of Perimenopause" by Stephanie DeGraff Bender, MA hosted by Sue Spataro, RN, BSN redchk.gif (175 bytes)

Heath benefits of soy â“ why the controversy?
We find adding soy to the diet useful for many women, particularly during perimenopause. But soy isnâ™t helpful for all women, and in some cases may be

Soy for menopausal symptoms
Soy has been closely studied and found supportive for a wide range of menopausal and perimenopausal concerns: improved insulin regulation; weight loss;

Symptoms of Perimenopause
Researchers continue to study the relationship between a soy-rich diet and female hormones. Although each woman experiences perimenopause (the period

perimenopause
Perimenopause, or pre-menopause is a transitional stage of two to ten years before complete Of these, the source said to be the most potent is soy.

Revival Soy -- Soy & Menopause and Perimenopause Discomforts Support
Menopause and soy health benefits for hot flashes and night sweats at RevivalSoy.com.

Can Soy Support Menopause, Perimenopause,&Postmenopause?
Menopause is a natural stage of life all women experience as they age. And while it may be normal, it certainly doesn't feel normal.

Soy May Support A Healthier Perimenopause & Menopause Transition
The transition to menopause is known as perimenopause, a process that begins 8-10 years before menopause and marks the beginning of declining hormone


perimenopause and soy
premenopause symptoms
menopause the musical regal
sex menopause tips
menopause vaginal infection