Study Finds Menopause Symptoms Can Be PredictedThe number of eggs left in a woman's ovaries are like the grains of sand in an hourglass, ticking away the hours on her biological clock.Researchers now say they may be able to predict when that clock will wind down. And while doctors can't actually count the number of eggs in an ovary, they can measure ovarian volume. British researchers say there's a direct correlation between the two, and by measuring ovarian volume with transvaginal ultrasound, doctors should be able to predict when menopause will set in and how many fertile years a woman has left. According to the study authors, this information will revolutionize the care of women looking for assisted reproductive technologies, including those who were treated for childhood cancers as well as women who want to put off starting a family for whatever reason. Although information still needs to be validated in clinical studies, its benefit is most likely to start with women who are being treated for cancer and women attending fertility clinics, said Tom Kelsey, co-author of the study appearing June 17 in the journal Human Reproduction. "If women looking for some sort of assisted conception and their physicians know that they've got a long time till menopause, then you could plan for a range of treatments," said Kelsey, who is a senior research fellow at the University of St. Andrews in Scotland. "If you knew menopause was likely in four to five years, you'd plan a different set of IVF [in vitro fertilization] treatments." Others reiterate, however, that the findings should be treated with caution. "Should a young woman who is 30 years old go for a test to figure out whether she's got three, five or 10 years left on her fertility? Should she make career decisions and life decisions? Are these data good enough to make those determinations?" asked Dr. Alan Copperman, director of reproductive medicine at Mount Sinai Medical Center in New York City. "The answer is obviously no to all of those questions. The predictive value of this test is not good enough to go and tell someone to change their life." According to the article, eggs form in a female's ovary while she is still in the womb, peaking at several million about halfway through gestation and then starting a continuous decline. At birth, there are several hundred thousand and, when menstruation begins, about 300,000. At about age 37, a woman has about 25,000 eggs left, and at menopause only about 1,000. The time at which menopause sets in is widely believed to be based on the number of eggs reaching a critically low threshold. The authors of this study measured ovarian volume with transvaginal ultrasound, then looked at the relationship between ovarian volume -- ovaries shrink as a woman ages -- and number of eggs. They then applied mathematical and computer models to predict menopause. The study authors are negotiating with a medical school to set up clinical trials. The idea would be to follow women to see if their predictions were indeed correct. While these authors have come up with a tool to potentially help women plan their lives, a second study in the same issue of Human Reproduction warned that women might not want to leave it too late. Assisted reproductive technology (ART) could not be relied upon to fully compensate for lack of natural fertility after the age of 35, the article stated. The authors used a computer simulation model to determine that the overall success rate of assisted reproductive technology would be 30 percent for those attempting to get pregnant from age 30, 24 percent for those trying from age 35, and 17 percent from age 40. SOURCES: Tom Kelsey, Ph.D., senior research fellow, University of St. Andrews, St. Andrews, Scotland; Alan Copperman, M.D., director, reproductive medicine, Mount Sinai Medical Center, New York; June 17, 2004, Human Reproduction |
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Reproductive Characteristics and the Age at Inception of the There was some evidence that early age at menarche and short menstrual cycles were associated with an earlier perimenopause. No relation was observed with Frequently Asked Questions About Menopause and Perimenopause -What Women tend to reach menopause at about the same age that their mother and sisters did, Treatments for perimenopause can include birth control pills, Menopause and Perimenopause What is menopause? What is perimenopause? Menopause is the point in a For most women, menopause happens around age 50, but every woman's body has its Getting pregnant during perimenopause at age 45 >> Medical I am 45 years old. The doctor said I am at the end of my perimenopause and it would take a miracle to get pregant. I desperately want a second child. Information on perimenopause and menopause at MedicineNet.com Women normally go through menopause between ages 45 and 55. Many women experience menopause around age 51. However, perimenopause can start as early as age perimenopause or pre-menopause and Night Sweats Before making a diagnosis of perimenopause, your doctor will take many things into consideration, including your age, menstrual history and what symptoms or Answers to FAQs and Articles about Perimenopause and early Answers to your most frequently asked questions FAQs about perimenopause and I began pre-menopause at age 38 - seven years ago - and have been on HRT Perimenopause, Hormone Therapy â“ Expert Advice Women experiencing premature menopause (age 40 or younger) that is not medically induced go through perimenopause and may have the same symptoms as women Perimenopause Remember menopause before the age of 40 is called premature menopause and is rare. However perimenopause can begin before age 40. Imaginis - Menopause Menopause is considered premature if it occurs before age 35. During peri-menopause, menstrual periods often become highly irregular and women may Menopause and Peri-Menopause Perimenopause can begin as early as age thirty, however, the average age is fifty-one. Some of the symptoms associated with perimenopause are as follows: Baptist Health Library - Detail And, with the average age of menopause being 51 years of age, that starting age for perimenopause could be as young as 41 years old. Menopause - Wikipedia, the free encyclopedia Symptoms of perimenopause can begin as early as age 35, although most women become aware of them about 10 years later than this. Perimenopause can last for Information About Perimenopause Hypothyroid occurs more often in women and in the same age groups as perimenopause. Menstrual irregularities are a major sign in women with thyroid. Perimenopause - WrongDiagnosis.com Perimenopause information including symptoms, diagnosis, misdiagnosis, treatment, (Source: excerpt from Menopause - Age Page - Health Information: NIA) Perimenopause definition - Menopause: Menopausal Health and Other changes associated with the perimenopause and menopause include night sweats, The age at menopause is not influenced by a woman's race, height, Perimenopause - CNN.com No one test or sign is enough to determine if you've entered perimenopause. Your doctor takes many things into consideration, including your age, Perimenopause: Hormone ups and downs can last years - CNN.com For most women, perimenopause happens after age 40, and can last anywhere from two to 10 years. While a shorter menstrual cycle is a reliable tipoff, RFA-AG-05-008: Biology of the Perimenopause: Impact on Health and Also, at the perimenopause serum levels of pituitary gonadotropins increase, problems and conditions associated with the menopause increase with age, |
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