Study Finds Menopause Symptoms Can Be Predicted

The number of eggs left in a woman's ovaries are like the grains of sand in an hourglass, ticking away the hours on her biological clock.

Researchers now say they may be able to predict when that clock will wind down.

And while doctors can't actually count the number of eggs in an ovary, they can measure ovarian volume. British researchers say there's a direct correlation between the two, and by measuring ovarian volume with transvaginal ultrasound, doctors should be able to predict when menopause will set in and how many fertile years a woman has left.

According to the study authors, this information will revolutionize the care of women looking for assisted reproductive technologies, including those who were treated for childhood cancers as well as women who want to put off starting a family for whatever reason.

Although information still needs to be validated in clinical studies, its benefit is most likely to start with women who are being treated for cancer and women attending fertility clinics, said Tom Kelsey, co-author of the study appearing June 17 in the journal Human Reproduction.

"If women looking for some sort of assisted conception and their physicians know that they've got a long time till menopause, then you could plan for a range of treatments," said Kelsey, who is a senior research fellow at the University of St. Andrews in Scotland. "If you knew menopause was likely in four to five years, you'd plan a different set of IVF [in vitro fertilization] treatments."

Others reiterate, however, that the findings should be treated with caution.

"Should a young woman who is 30 years old go for a test to figure out whether she's got three, five or 10 years left on her fertility? Should she make career decisions and life decisions? Are these data good enough to make those determinations?" asked Dr. Alan Copperman, director of reproductive medicine at Mount Sinai Medical Center in New York City. "The answer is obviously no to all of those questions. The predictive value of this test is not good enough to go and tell someone to change their life."

According to the article, eggs form in a female's ovary while she is still in the womb, peaking at several million about halfway through gestation and then starting a continuous decline. At birth, there are several hundred thousand and, when menstruation begins, about 300,000. At about age 37, a woman has about 25,000 eggs left, and at menopause only about 1,000.

The time at which menopause sets in is widely believed to be based on the number of eggs reaching a critically low threshold.

The authors of this study measured ovarian volume with transvaginal ultrasound, then looked at the relationship between ovarian volume -- ovaries shrink as a woman ages -- and number of eggs. They then applied mathematical and computer models to predict menopause.

The study authors are negotiating with a medical school to set up clinical trials. The idea would be to follow women to see if their predictions were indeed correct.

While these authors have come up with a tool to potentially help women plan their lives, a second study in the same issue of Human Reproduction warned that women might not want to leave it too late. Assisted reproductive technology (ART) could not be relied upon to fully compensate for lack of natural fertility after the age of 35, the article stated.

The authors used a computer simulation model to determine that the overall success rate of assisted reproductive technology would be 30 percent for those attempting to get pregnant from age 30, 24 percent for those trying from age 35, and 17 percent from age 40.

SOURCES: Tom Kelsey, Ph.D., senior research fellow, University of St. Andrews, St. Andrews, Scotland; Alan Copperman, M.D., director, reproductive medicine, Mount Sinai Medical Center, New York; June 17, 2004, Human Reproduction

per menopause
Health & Medical News - Early menopause is strongly genetic - 30
For non-twin sisters, it was estimated that age at menopause was 85 to 87 per cent due to genetic factors. In twins it was 70 to 71 per cent, which was not

Menopause | Mennopause
For male Menopause, NAMS menopause; Center Find Menopause NAMS menopause, symptoms, and possible Treatments, per each menopausal symptoms, of menopause

India Together: Premature menopause alarm for Indian women - 8
Overall, the percentage of women hit by premature menopause is marginally lower in urban areas (16.1 per cent) as against rural (18.3 per cent).

New research putting men back into 'men'opause
Of those respondents (142) who had experienced their partner's menopause, almost 50 per cent of men said it had impacted negatively on their sex life,

Prices for Menopause Specialist herbal formula with Phyto Estrogen
One bottle of Menopause Specialist contains 60 capsules and provides a 30-day supply when 2 capsules per day are taken. Dr. Tai's Menopause Specialist

JAMA -- Abstract: Postmenopausal Hormone Therapy and Risk of
The estimated absolute excess risk for CHD for women within 10 years of menopause was â“6 per 10 000 person-years; for women 10 to 19 years since menopause

symptoms of per menopause - www.symptonsofperimenopause.com
symptonsofperimenopause.com symptoms of per menopause.

symptom of per menopause - www.symptomofperimenopause.com
symptomofperimenopause.com symptom of per menopause.

Women's Health and Menopause (washingtonpost.com)
When I was evaluated by my doctor, he said that while I was not in menopause, I was most likely in per menopause, and suggested that I go back on the pill.

All Natural Menopause Relief
"When women go into per menopause, they don't need to worry about cognitive decline," said Dr. Jong-Ling Fuh, an attending physician at Taipei Veterans

CNW Telbec | WYETH CANADA | Largest Canadian survey on menopause
While 72 per cent of women feel knowledgeable about menopause, less than 30 per cent consider this knowledge to be very good. That number drops to less than

Counting human somatic cell replications: Methylation mirrors
Multiparity (blue line) is simulated with 0.75 divisions per day between menarche and menopause. Obesity (red line) is simulated with 1.25 divisions per day

HealthShip > Catalog > Menopause > Black Cohosh One Per Day
As one of our "All You Need is One" Herbals, this black cohosh is a high potency 80mg per capsule extract. For women experiencing menopause, Black cohosh is

Amazon.com: Extra Strength Estroven - Menopause Relief - 98
Extra Strength Estroven - Menopause Relief - 98 Caplets -Two Per Day Dose Take two caplets once per day, near mealtime, to realize full benefits.

M.A.R.L.B.O.R.OF.O.R11.99P.E.RC.A.R.T.O.N.
Newsgroups: alt.support.menopause.husbands. From: lard@hotmail.com (Beth U. Kutchaver) F.O.R11.99P.E.RC.A.R.T.O.N..lEqTi6ojil

Am I having miscarriages or is it early per menopause? - Women's
This is a discussion on MedHelp about Am I having miscarriages or is it early per menopause?. Community members of MedHelp provide help, support,

Womens HealthCare Forum: Menopause
The goal should be to reach a total daily intake of 1000 milligrams per day before menopause or 1500 milligrams per day after menopause.

The menopause
The menopause, also called the change of life, is defined as the end of the and 30-90 per cent of women still get some menstrual bleeding afterwards,

Early Menopause Symptoms
Before the periods stop, one goes through a transition period called per menopause. One can notice various early menopause symptoms to determine for sure


per menopause
pregnancy after menopause
menopause menstruation
peremenopause
post menopause weight gain