Study Finds Menopause Symptoms Can Be PredictedThe number of eggs left in a woman's ovaries are like the grains of sand in an hourglass, ticking away the hours on her biological clock.Researchers now say they may be able to predict when that clock will wind down. And while doctors can't actually count the number of eggs in an ovary, they can measure ovarian volume. British researchers say there's a direct correlation between the two, and by measuring ovarian volume with transvaginal ultrasound, doctors should be able to predict when menopause will set in and how many fertile years a woman has left. According to the study authors, this information will revolutionize the care of women looking for assisted reproductive technologies, including those who were treated for childhood cancers as well as women who want to put off starting a family for whatever reason. Although information still needs to be validated in clinical studies, its benefit is most likely to start with women who are being treated for cancer and women attending fertility clinics, said Tom Kelsey, co-author of the study appearing June 17 in the journal Human Reproduction. "If women looking for some sort of assisted conception and their physicians know that they've got a long time till menopause, then you could plan for a range of treatments," said Kelsey, who is a senior research fellow at the University of St. Andrews in Scotland. "If you knew menopause was likely in four to five years, you'd plan a different set of IVF [in vitro fertilization] treatments." Others reiterate, however, that the findings should be treated with caution. "Should a young woman who is 30 years old go for a test to figure out whether she's got three, five or 10 years left on her fertility? Should she make career decisions and life decisions? Are these data good enough to make those determinations?" asked Dr. Alan Copperman, director of reproductive medicine at Mount Sinai Medical Center in New York City. "The answer is obviously no to all of those questions. The predictive value of this test is not good enough to go and tell someone to change their life." According to the article, eggs form in a female's ovary while she is still in the womb, peaking at several million about halfway through gestation and then starting a continuous decline. At birth, there are several hundred thousand and, when menstruation begins, about 300,000. At about age 37, a woman has about 25,000 eggs left, and at menopause only about 1,000. The time at which menopause sets in is widely believed to be based on the number of eggs reaching a critically low threshold. The authors of this study measured ovarian volume with transvaginal ultrasound, then looked at the relationship between ovarian volume -- ovaries shrink as a woman ages -- and number of eggs. They then applied mathematical and computer models to predict menopause. The study authors are negotiating with a medical school to set up clinical trials. The idea would be to follow women to see if their predictions were indeed correct. While these authors have come up with a tool to potentially help women plan their lives, a second study in the same issue of Human Reproduction warned that women might not want to leave it too late. Assisted reproductive technology (ART) could not be relied upon to fully compensate for lack of natural fertility after the age of 35, the article stated. The authors used a computer simulation model to determine that the overall success rate of assisted reproductive technology would be 30 percent for those attempting to get pregnant from age 30, 24 percent for those trying from age 35, and 17 percent from age 40. SOURCES: Tom Kelsey, Ph.D., senior research fellow, University of St. Andrews, St. Andrews, Scotland; Alan Copperman, M.D., director, reproductive medicine, Mount Sinai Medical Center, New York; June 17, 2004, Human Reproduction |
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Hormone Therapy Given Closer to Menopause Onset Is Safest Coronary heart disease risk linked with hormone therapy is not increased significantly in women who take hormone therapy within 10 years of the onset of Date of birth linked to onset of menopause | Society | The Guardian Date of birth could influence the age at which a woman reaches the menopause, say Italian researchers who studied almost 3000 post-menopausal women. Maturitas : On adaptive onset hypothesis (AOH) of menopause Most (but not all) studies have suggested that parity is linked with age at onset of menopause: nulliparous women have an early menopause 2, 3, 4, Onset of Natural Menopause in African American Women Cox proportional hazards regression was used to assess potential predictorsâ”including experiences of racismâ”of the onset of natural menopause among 17 070 Maturitas : Seasonal onset of the menopause - Published by Elsevier In order to evaluate any temporal relationship between the eventual rhythm of menopause onset and that of reproduction, the seasonal rhythm of conceptions Birth month tied to menopause onset On average, there was 18 months' difference in onset between women born in October, reaching menopause at an average age of 50 years, 3 months, Mayo Clinic - Managing Early-Onset Menopause Treatment-induced menopause: Certain surgical or medical treatments can cause early-onset menopause, including ovary removal, chemotherapy or radiation Health 24 - Menopause, Age and menopause The later onset of menopause? Last updated: Tuesday, May 15, 2007. It has been known that the age of menarche (having the first menstrual period) is Onset of menopause symptoms Onset of menopause symptoms, they think of hot flashes and osteoporosis, but there are many lesser known, but just as disruptive, physical changes. Perimenopausal and menopausal bleeding The average age of the onset of menopause is 51 years, and it is most commonly occurs from age 47 to 53. Perimenopause is the period immediately before and Age at onset of menopause Age of menarche related to age of menopause? Dr. Kisch generalises on the relation between the age of onset of menstruation and the age at which it ceases. Age at the Onset of Menopause at Menopause Insight Menopause Insight is an interesting and informative guide designed to educate people about the effects of menopause. Review the excellent information we Managing Early-Onset Menopause Menopause, which marks the end of a woman's reproductive years, usually occurs around age 50 or 51. But for various reasons, some women experience early Menopause - Message Board Q. You stated that menopause onset occurs between 45 and 55 years of age. Is there any evidence which suggests that menopause onset is occuring later in Average Age of Menopause Onset and What Age is Menopause Average age of menopause, menopause defined, age and first signs of menopause, what age is menopause, average age of menopause, average age of menopause Menopause symptoms, diagnosis, and treatment on MedicineNet.com The age at which a woman starts having menstrual periods is also not related to the age of menopause onset. Most women reach menopause between the ages of Onset Of Menopause May Be Linked To Seasons Fertility researchers in Hungary have revealed that the onset of menopause may not only be dictated by the fact that a woman's lifetime supply of eggs is Season Of Birth Influences Onset Of Menopause The earliest age of menopause onset was found in women born in March and the latest among those born in October. On average there was around 15 months FOXNews.com - Menopause Onset Raises Depression Risk - Health News Menopause Onset Raises Depression Risk, Women approaching menopause are at increased risk for depression, and two new studies offer some of the strongest |
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