Study Finds Menopause Symptoms Can Be Predicted

The number of eggs left in a woman's ovaries are like the grains of sand in an hourglass, ticking away the hours on her biological clock.

Researchers now say they may be able to predict when that clock will wind down.

And while doctors can't actually count the number of eggs in an ovary, they can measure ovarian volume. British researchers say there's a direct correlation between the two, and by measuring ovarian volume with transvaginal ultrasound, doctors should be able to predict when menopause will set in and how many fertile years a woman has left.

According to the study authors, this information will revolutionize the care of women looking for assisted reproductive technologies, including those who were treated for childhood cancers as well as women who want to put off starting a family for whatever reason.

Although information still needs to be validated in clinical studies, its benefit is most likely to start with women who are being treated for cancer and women attending fertility clinics, said Tom Kelsey, co-author of the study appearing June 17 in the journal Human Reproduction.

"If women looking for some sort of assisted conception and their physicians know that they've got a long time till menopause, then you could plan for a range of treatments," said Kelsey, who is a senior research fellow at the University of St. Andrews in Scotland. "If you knew menopause was likely in four to five years, you'd plan a different set of IVF [in vitro fertilization] treatments."

Others reiterate, however, that the findings should be treated with caution.

"Should a young woman who is 30 years old go for a test to figure out whether she's got three, five or 10 years left on her fertility? Should she make career decisions and life decisions? Are these data good enough to make those determinations?" asked Dr. Alan Copperman, director of reproductive medicine at Mount Sinai Medical Center in New York City. "The answer is obviously no to all of those questions. The predictive value of this test is not good enough to go and tell someone to change their life."

According to the article, eggs form in a female's ovary while she is still in the womb, peaking at several million about halfway through gestation and then starting a continuous decline. At birth, there are several hundred thousand and, when menstruation begins, about 300,000. At about age 37, a woman has about 25,000 eggs left, and at menopause only about 1,000.

The time at which menopause sets in is widely believed to be based on the number of eggs reaching a critically low threshold.

The authors of this study measured ovarian volume with transvaginal ultrasound, then looked at the relationship between ovarian volume -- ovaries shrink as a woman ages -- and number of eggs. They then applied mathematical and computer models to predict menopause.

The study authors are negotiating with a medical school to set up clinical trials. The idea would be to follow women to see if their predictions were indeed correct.

While these authors have come up with a tool to potentially help women plan their lives, a second study in the same issue of Human Reproduction warned that women might not want to leave it too late. Assisted reproductive technology (ART) could not be relied upon to fully compensate for lack of natural fertility after the age of 35, the article stated.

The authors used a computer simulation model to determine that the overall success rate of assisted reproductive technology would be 30 percent for those attempting to get pregnant from age 30, 24 percent for those trying from age 35, and 17 percent from age 40.

SOURCES: Tom Kelsey, Ph.D., senior research fellow, University of St. Andrews, St. Andrews, Scotland; Alan Copperman, M.D., director, reproductive medicine, Mount Sinai Medical Center, New York; June 17, 2004, Human Reproduction

menopause stage play
The Stage / Reviews / Menopause the Musical
The Stage is the newspaper for the performing arts industry. Tenuous plot devices are put into play as four women meet and spend hours in the Marble

Menopause and Desire: Or Why Must I Be Middle Aged and In Love?
She recently completed a new play celebrating the history of the San Francisco Women's He teaches courses in writing and adaptation for the stage,

The Menopause Domain
Gain weight during menopause stage, however, may be countered albeit cannot Urinary problems Á“ estrogen loss has been discovered to play a role in the

Menopause Symptoms and Treatments
The causes of irregular and abundant bleeding in women in the menopause stage are due to the absence of ovulation, which causes, as a consequence,

Menopause the Musical stage critique
MENOPAUSE THE MUSICAL: G-Four Productions Vivien Davies play the Soap Star as a sort of Antipodean Joanna Lumley, and Susan-Ann Walker is very endearing

Germaine Greer on ÁśMenopause the MusicalÁ«: New Heights in Bad
Some women come back again and again with their friends and laugh and dance on stage at the end every time. IÁ™ve seen so many women enjoying this play that

Post-Standard Critics on Syracuse.com: Syracuse Stage
Well-done as the play is, though, the story seems plodding. Review of "Menopause,the Musical" by Chuck Klaus. Who: Syracuse Stage.

Menopause Out Loud! - Cause To Celebrate
The smash stage hit Menopause: The Musical Á„˘ was originally entitled Menopause Out Loud to Empowerment Foundation, financed by the proceeds of her play.

Reviews/Theater; Male Menopause, in All Its Flattering Aspects
but in that smoke-filled men's club known as the English theater, male menopause still hogs center stage. "The Holy Terror," Simon Gray's play at the

Female Infertility Herbs for PMS Remedy Herbs Menopause Relief
This is followed by the Vata stage of live, a time of inner reflection and growth. It is a time of service, to our loved ones and our society. Menopause

Curtrain Up Awards
Tin Box Boomerang, Yvonne Azurdia Best Ensemble Production (play or musical) Blood Brothers @ Shores Theatre Menopause @ Stage Door Theatre

Menopause The Musical at Syracuse Stage
"Menopause The Musical" at Syracuse Stage. "Menopause the Musical" is written by Cost: Play $26.00 (must pay ahead) - Dinner Per Your Order that Evening

Menopause Symptoms Antiaging: Dallas Chiropractor Lewis Cone
Syracuse Stage is Central New York's only professional theatre. The theatre produces seven mainstage plays, one mainstage young people's play and one

More 'Menopause' on Cap Rep stage -- Page 1 -- Times Union - Albany NY
More 'Menopause' on Cap Rep stage. By DANIELL E FURFARO, Staff writer The play, inspired by Hans Christian Anderson's fairy tale "The Little Match Girl

Menopause Symptoms - 8 Signs You May Have Menopause
You have the pre-menopause stage when the ovaries are shutting, The bottom line is, a doctor will have more of an idea that menopause is at play by

How to stage a coup - Arts - www.theage.com.au
to the Playhouse stage in February to play the lead in the French classic, following Menopause the Musical, which opens at the Comedy in February.

On Stage - Theater - The Stranger, Seattle's Only Newspaper
The premiere play of David Esbjornson's premiere season at the Seattle Rep is that someone dragged me to see Menopause the motherfucking MusicalÁ„˘, and,

Get Out! Amarillo's Entertainment Guide :: 'Menopause' Heats Up Stage
'Menopause' Heats Up Stage Now, she has a play that has been seen by more than 6 million women since 2001, according to her production company's

Theatre/Dance
The convention of cohesively uniting the elements of a musical play began with a new kind of musical emerged, not on the Broadway stage, but in smaller


menopause stage play
premenopause sign
signs menopause
menopause play boston ma
perimenopause list of symptoms