Study Finds Menopause Symptoms Can Be Predicted

The number of eggs left in a woman's ovaries are like the grains of sand in an hourglass, ticking away the hours on her biological clock.

Researchers now say they may be able to predict when that clock will wind down.

And while doctors can't actually count the number of eggs in an ovary, they can measure ovarian volume. British researchers say there's a direct correlation between the two, and by measuring ovarian volume with transvaginal ultrasound, doctors should be able to predict when menopause will set in and how many fertile years a woman has left.

According to the study authors, this information will revolutionize the care of women looking for assisted reproductive technologies, including those who were treated for childhood cancers as well as women who want to put off starting a family for whatever reason.

Although information still needs to be validated in clinical studies, its benefit is most likely to start with women who are being treated for cancer and women attending fertility clinics, said Tom Kelsey, co-author of the study appearing June 17 in the journal Human Reproduction.

"If women looking for some sort of assisted conception and their physicians know that they've got a long time till menopause, then you could plan for a range of treatments," said Kelsey, who is a senior research fellow at the University of St. Andrews in Scotland. "If you knew menopause was likely in four to five years, you'd plan a different set of IVF [in vitro fertilization] treatments."

Others reiterate, however, that the findings should be treated with caution.

"Should a young woman who is 30 years old go for a test to figure out whether she's got three, five or 10 years left on her fertility? Should she make career decisions and life decisions? Are these data good enough to make those determinations?" asked Dr. Alan Copperman, director of reproductive medicine at Mount Sinai Medical Center in New York City. "The answer is obviously no to all of those questions. The predictive value of this test is not good enough to go and tell someone to change their life."

According to the article, eggs form in a female's ovary while she is still in the womb, peaking at several million about halfway through gestation and then starting a continuous decline. At birth, there are several hundred thousand and, when menstruation begins, about 300,000. At about age 37, a woman has about 25,000 eggs left, and at menopause only about 1,000.

The time at which menopause sets in is widely believed to be based on the number of eggs reaching a critically low threshold.

The authors of this study measured ovarian volume with transvaginal ultrasound, then looked at the relationship between ovarian volume -- ovaries shrink as a woman ages -- and number of eggs. They then applied mathematical and computer models to predict menopause.

The study authors are negotiating with a medical school to set up clinical trials. The idea would be to follow women to see if their predictions were indeed correct.

While these authors have come up with a tool to potentially help women plan their lives, a second study in the same issue of Human Reproduction warned that women might not want to leave it too late. Assisted reproductive technology (ART) could not be relied upon to fully compensate for lack of natural fertility after the age of 35, the article stated.

The authors used a computer simulation model to determine that the overall success rate of assisted reproductive technology would be 30 percent for those attempting to get pregnant from age 30, 24 percent for those trying from age 35, and 17 percent from age 40.

SOURCES: Tom Kelsey, Ph.D., senior research fellow, University of St. Andrews, St. Andrews, Scotland; Alan Copperman, M.D., director, reproductive medicine, Mount Sinai Medical Center, New York; June 17, 2004, Human Reproduction

menopause rating scale
Best Practice & Research Clinical Obstetrics & Gynaecology
Experience utilizing the Menopause Rating Scale in a Berlin study established different types of menopause coping styles. The most important factors

Black cohosh: state of the science and art | Townsend Letter for
The Wuttke study (5) demonstrated a statistically significant reduction in the Menopause Rating Scale in women taking black cohosh and taking black cohosh

Uplifting News for a Hot Topic
To assess menopausal symptoms The Menopause Rating Scale was used. The scale consists of 10 items and to participate in the study, a rating of 0.4 was

Nutrafem Research
Effect of Nutrafem^on the Scores of the Individual Menopause Rating Scale (MRS) Symptoms. Effect of Nutrafem^on the Severity of the Dimensions of the

climacteric and depressive symptoms Black cohosh and St Johns
Menopause Rating Scale score >0.4 on >3 items, a Hamilton. Depression Rating Scale Menopause Rating Scale scores. It would have been useful to have 4

Thieme-connect - Abstract
The Menopause Rating Scale (MRS) is a well accepted instrument to measure the severity of menopausal symptoms. As yet, however, investigations had not

Menopause - Fulltext: Volume 14(4) July/August 2007 p 810 Letters
Validated Russian versions of the Menopause Rating Scale (MRS) and the Psychological General Well-being Index (PGWBI)2,3 were obtained from the MAPI

Science Links Japan | A Menopause Rating Scale for quality of life
Title;A Menopause Rating Scale for quality of life assessment. Author;SCHNEIDER H P G(Univ. Muenster, Muenster, Deu). Journal Title;Advances in Obstetrics

IngentaConnect Application and factor analysis of the menopause
Objectives: The menopause rating scale (MRS) has been developed as a modern tool for the assessment of menopausal complaints.

Health and Quality of Life Outcomes | Full text | The Menopause
The Menopause Rating Scale (MRS) scale: A methodological review The Menopause Rating Scale (MRS) is a health-related quality of life scale (HRQoL) and

The Menopause Rating Scale (MRS) scale: A methodological review
The Menopause Rating Scale (MRS) is a health-related quality of life scale (HRQoL) and was developed in response to the lack of standardized scales to

IngentaConnect The menopause rating scale (MRS II) - clusters of
We report the results of an evaluation of the revised form of the Menopause-Rating-Scale (MRS II). In 1996 it was applied in a representative sample of 479

Health and Quality of Life Outcomes | Full text | The Menopause
The Menopause Rating Scale (MRS) as outcome measure for hormone treatment? The Menopause Rating Scale is a health-related Quality of Life scale

A new rating scale for the climacteric syndrome (Menopause Rating
In 1994, an expert group of German, Austrian and Swiss members published a new score (Menopause Rating Scale MRS) selectively adopting most of the

The Menopause Rating Scale (MRS): reliability of scores of
OBJECTIVE: To analyze the reliability of scores of the recently developed self-administrative Menopause Rating Scale (MRS) in a follow-up investigation of a

The Menopause Rating Scale (MRS) as outcome measure for hormone
The Menopause Rating Scale is a health-related Quality of Life scale developed in the early 1990s and step-by-step validated since then.

MRS - Menopause Rating Scale
MRS - Menopause Rating Scale.

International versions of the Menopause Rating Scale (MRS)
The Menopause Rating Scale (MRS) is a formally validated scale according to the requirements for quality of life instruments. The aim of this paper is to


menopause rating scale
menopause stage play
per menopause
menopause heavy periods
post menopause weight loss