Study Finds Menopause Symptoms Can Be PredictedThe number of eggs left in a woman's ovaries are like the grains of sand in an hourglass, ticking away the hours on her biological clock.Researchers now say they may be able to predict when that clock will wind down. And while doctors can't actually count the number of eggs in an ovary, they can measure ovarian volume. British researchers say there's a direct correlation between the two, and by measuring ovarian volume with transvaginal ultrasound, doctors should be able to predict when menopause will set in and how many fertile years a woman has left. According to the study authors, this information will revolutionize the care of women looking for assisted reproductive technologies, including those who were treated for childhood cancers as well as women who want to put off starting a family for whatever reason. Although information still needs to be validated in clinical studies, its benefit is most likely to start with women who are being treated for cancer and women attending fertility clinics, said Tom Kelsey, co-author of the study appearing June 17 in the journal Human Reproduction. "If women looking for some sort of assisted conception and their physicians know that they've got a long time till menopause, then you could plan for a range of treatments," said Kelsey, who is a senior research fellow at the University of St. Andrews in Scotland. "If you knew menopause was likely in four to five years, you'd plan a different set of IVF [in vitro fertilization] treatments." Others reiterate, however, that the findings should be treated with caution. "Should a young woman who is 30 years old go for a test to figure out whether she's got three, five or 10 years left on her fertility? Should she make career decisions and life decisions? Are these data good enough to make those determinations?" asked Dr. Alan Copperman, director of reproductive medicine at Mount Sinai Medical Center in New York City. "The answer is obviously no to all of those questions. The predictive value of this test is not good enough to go and tell someone to change their life." According to the article, eggs form in a female's ovary while she is still in the womb, peaking at several million about halfway through gestation and then starting a continuous decline. At birth, there are several hundred thousand and, when menstruation begins, about 300,000. At about age 37, a woman has about 25,000 eggs left, and at menopause only about 1,000. The time at which menopause sets in is widely believed to be based on the number of eggs reaching a critically low threshold. The authors of this study measured ovarian volume with transvaginal ultrasound, then looked at the relationship between ovarian volume -- ovaries shrink as a woman ages -- and number of eggs. They then applied mathematical and computer models to predict menopause. The study authors are negotiating with a medical school to set up clinical trials. The idea would be to follow women to see if their predictions were indeed correct. While these authors have come up with a tool to potentially help women plan their lives, a second study in the same issue of Human Reproduction warned that women might not want to leave it too late. Assisted reproductive technology (ART) could not be relied upon to fully compensate for lack of natural fertility after the age of 35, the article stated. The authors used a computer simulation model to determine that the overall success rate of assisted reproductive technology would be 30 percent for those attempting to get pregnant from age 30, 24 percent for those trying from age 35, and 17 percent from age 40. SOURCES: Tom Kelsey, Ph.D., senior research fellow, University of St. Andrews, St. Andrews, Scotland; Alan Copperman, M.D., director, reproductive medicine, Mount Sinai Medical Center, New York; June 17, 2004, Human Reproduction |
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Approaching Menopause The menstrual period may occur irregularly and may be quite heavy. Other cycles may produce a light menstrual period. As perimenopause moves into menopause, Menopause symptoms, diagnosis, and treatment on MedicineNet.com After six years, many of the women were experiencing hot flashes and irregular menstrual periods, two signs of approaching menopause. Menstrual Cycles: What Really Happens in those 28 Days?! Technically menopause is the last menstrual flow of a woman's life and the climacteric is period of time preceding and following this event. Menstruation and the Menstrual Cycle Most menstrual periods last from three to five days. . Like menstruation, menopause can vary from woman to woman and these changes may take several years Abnormal vaginal bleeding - causes of irregular, heavy menstrual The usual cause of vaginal bleeding is the menstrual period, any irregular Around the time of the menopause, menstrual bleeding often becomes irregular, Understanding your menstrual cycle The cycle starts with the first day of the menstrual period (referred to as day . In the time leading up to the menopause the menstrual cycle and/or flow Menopause and Menstrual Cycles - womenshealthchannel To understand what happens hormonally during perimenopause and menopause, it helps to understand what happens hormonally during the menstrual cycle. Irregular Menstrual Periods in Perimenopause and Menopause Irregular periods are a common symptom of perimenopause, the time before menopause itself. You may experience a change in the menstrual cycle, Irregular periods - understanding the menstrual cycle Explains irregular periods, the causes of irregular menstrual cycles, (the first period in a womanâ™s life) earlier would enter menopause earlier. Menopause Perimenopause Mature Sexuality Aging HRT Womens Health Menopause is your last monthly period and represents the ending of the active functioning of your ovaries. menopause changes in menstrual cycle Menopause, Hormones, The Menstrual Cycle, Hormone Replacement Hormones And The Menstrual Cycle. How hormones affect the menopause. In order to understand what happens during perimenopause and menopause, and how hormone |
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